National Institute of Pharmaceutical Education and Researc...

National Institute of Pharmaceutical Education and Research Joint Entrance Exam

National Institute of Pharmaceutical Education and Research Joint Entrance Exam - exam_syllabus

Entrance exam for PG and doctoral programs in pharmaceutical sciences at NIPER institutes.

The National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, which is in charge of holding the exam, created the NIPER JEE 2024 syllabus. There are 200 multiple-choice questions in the two-hour computer-based NIPER JEE test.

Candidates can check to the detailed syllabus in the table below:

Subjects Topics
Natural Products
  1. Phytochemistry
  2. Secondary metabolites
  3. Methods of extraction, isolation, and characterization of natural products
  4. Important therapeutic classed
  5. Biosynthetic pathways
  6. Primary metabolites
  7. Marine natural products
  8. Plant growth regulators
  9. Spectroscopy
  10. Dietary antioxidants
Stereochemistry
  1. Pharmacology and toxicology
  2. Evaluation of formulation, principles, and methods of release control in oral formulations
  3. Bioavailability, bioequivalence studies
  4. Compartmental modelling
  5. Packaging
  6. Dosage forms
  7. Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities
  8. (TDDS)
  9. Fischer, sawhorse and Newman projection formulas
  10. Standardization of natural products
  11. Various adrenergic, cholinergic and other receptors
  12. Pharmaceutics and formulation (Pharmaceutical Technology)
  13. Pharmacokinetics
  14. Pharmacodynamics
  15. The pharmacological effect, desired, undesired, toxic, adverse effects
  16. Bioavailability, bioequivalence, various factors of ADME
  17. Drug metabolism
  18. Drug interactions, agonist, antagonist, protein binding, drug distribution, distribution volume, excretion pathways
  19. Pharmacological screening
  20. Mechanism of drug action
  21. Drug-receptor interaction
  22. Detailed study of CNS pharmacology Transdermal drug delivery systems
  23. Diseases
  24. Chemotherapy and pathophysiology
  25. Bioassay methods
  26. Drug delivery systems (DDS)
  27. Carriers in DDS
  28. Biological sources of important classes of natural products
  29. Parenteral
  30. Drug targeting
  31. Complexation
  32. Solubilisation
  33. Dosage form development- stages, implications of dosage form
  34. Viscosity measurements
Pharmaceutical analysis
  1. Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf-life determination, thermal stability, formulation stability
  2. Various analytical techniques
  3. Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests.
  4. Solubility
  5. Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS.
  6. Carriers in DDS: polymers and their classification, types, carbohydrates, surfactants, proteins, lipids, prodrugs etc.
  7. Drug delivery systems (DDS): NDDS models, osmotic pumps, various release patterns
  8. Osmolality, osmolality, osmotic pressure, conductivity, Preservatives, Media for bioassay.
  9. Spectroscopic methods
  10. Electrophoresis
  11. UV-Visible
  12. NMR
  13. XRD
  14. IR
  15. Fluorimetry
  16. HPLC
  17. IR
  18. GC
  19. LCMS
  20. Mass
  21. NMR Peaks
  22. Particle sizing
  23. Chromatography- detailed QA and QC: GLP, TQM, ISO system
  24. Pre-formulation, cyclodextrin inclusion compounds
  25. Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties.
  26. Dosage forms, Stages of dosage form development
Biotechnology and biochemistry
  1. Pharmaceutical technology
  2. Classification of enzymes and the mechanism of their function of action of
  3. Genetic Engineering
  4. Blotting techniques(Western, southern)
  5. Gel electrophoresis
  6. Gene cloning
  7. Immunoassays, protein
  8. RNA synthesis
  9. DNA synthesis
  10. RDNA technology
Gene expression
  1. Mutation
  2. Replication
  3. Transcription
  4. Translation
  5. Recombination
  6. Bacteriophages
Cloning
  1. Fermentation Methods
  2. isolation of nucleic acids
  3. enzymes in cloning
Chemistry
  1. Basic organic chemistry and biochemistry Stereochemistry
  2. Osazone test
  3. Mutarotation
  4. Medicinal chemistry and Bulk Drugs
  5. Keto-enol tautomerism
  6. IUPAC nomenclature
  7. Introduction to thermal methods of analysis
  8. Introduction to Redox reactions
  9. Imine-enamine
  10. Hybridization
  11. Amino acids proteins
  12. Type of stereoisomer
  13. Basic methods of synthesis of various organic compounds
  14. Named reactions
  15. Various Heterocycles, Heterocycle synthesis, reactions
  16. Tautomerism
  17. Spectroscopy
  18. Resolution methods
  19. Reaction kinetics, first second third and pseudo-first-order reactions, radiolabeling for determination of mechanism.
  20. Racemic mixture
  21. R and S nomenclature
  22. Reactions like Cannizarro’s reaction
  23. Pericyclic reactions
  24. Ester hydrolysis
  25. Huckel’s rule reaction mechanisms-
  26. E and Z isomerism
  27. Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen
  28. Chromatography
  29. Carbohydrates classification
  30. Aromaticity
Aptitude
  1. Simple Mathematics
  2. logical reasoning and data analysis,
  3. questions based on the English language
Pharmacology
  1. Bioavailability, bioequivalence, various factors of ADME
  2. Bioassay methods, various requirements. Brief knowledge of the statistical tests.
  3. Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases.
  4. Diseases: a study of the pharmacology of the diseases and drugs used with the mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodulation.
  5. Study of the basis of threshold areas of work in NIPER in the pharmacology dept. Mentioned in the brochure.
  6. Detailed study of CNS pharmacology especially opioid receptors
  7. Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects.
  8. Drug metabolism: various pathways and other details.
  9. Drug interactions, agonist, antagonist, Mechanism of drug action, drug-receptor interaction.
  10. Various adrenergic, cholinergic and other receptors
  11. Partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc.
Phytochemistry
  1. Methods of extraction, isolation, and characterization of natural products.
  2. Various separation techniques used for the isolation of natural products.
  3. Biosynthetic pathways.
  4. Primary metabolites, their examples
  5. Secondary metabolites, various classes of secondary metabolites (Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, etc.).
  6. Important therapeutic classes: anti-diabetics, hepato-protectives, immunomodulators, nutraceuticals, natural products for gynaecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc.
  7. Dietary antioxidants, Marine natural products, plant growth regulators.
  8. Fischer projection formulas.
  9. Biological sources of important classes of natural products. (Selected ones only)
  10. Standardisation of natural products, analytical pharmacognosy.
  11. Difference between natural products and pharmacognosy
  12. Some knowledge about types and preparation of ayurvedic formulations like asava, arista etc.